Abstract
Abstract—Acid and alkaline DNase activities were determined in postnatal and adult rat cerebellum. Normal animals were compared with those injected with 10 mg/kg methylazoxymethanol acetate using varying schedules after birth in order to induce transient damage to proliferating cell populations. In all animals studied, both immature and adult, methylazoxymethanol caused an increase in acidic and decrease in alkaline DNase activity. These effects were not specific to the dividing populations and occurred in nonmitotic cells as well. When injections were given to young adults, these effects appeared irreversible and persisted up to 3 months after birth.
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