Abstract

Abstract—The levels of DNA, RNA, protein and activities of acid and alkaline DNases in developing and old chicken brain were studied. A rapid increase in DNA content was found in the embryonic brain until just prior to hatching. Thereafter, with a transient plateau around the day of hatching, the DNA continued to increase but at a very slow rate. Two‐year‐old brain was found to have a markedly higher level of DNA as compared to the 10th day postnatal value. RNA showed a steady increase up to the 20th day of embryonic life. Protein levels showed a gradual increase throughout the period studied. Both acid and alkaline DNases exhibited maximum activity during embryonic life, i.e. at a time when rapid cellular proliferation was occurring. With advancing age, the acid DNase activity showed a marked decline thus exhibiting no correlation to the high level of DNA found in the old brain. The alkaline DNase activity, however, was still at a significant level in the 2‐year‐old brain.

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