Abstract
Denture stomatitis is a multifactorial pathological condition of the oral mucosa that affects up to 72% of denture wearers. It is commonly seen on the palatal mucosa and characterized by erythema on the oral mucosa that are in contact with the denture surface. The aim of this study was to incorporate 2-methacryloyloxyethyl phosphorylcholine (MPC) and dimethylaminohexadecyl methacrylate (DMAHDM) into a high impact polymethylmethacrylate heat-cured denture base acrylic resin as a potential treatment for denture stomatitis. We used a comparative study design to examine the effect of incorporating MPC as a protein repellent agent and DMAHDM as an antifungal agent to prevent the adherence of Candida albicans to the denture base material. The dual incorporation of MPC and DMAHDM reduced C. albicans biofilm colony-forming unit by two orders of magnitude when compared to the control group devoid of the bioactive agents. Although the addition of MPC and DMAHDM alone or in combination significantly reduced the flexural strength of the material, they showed reduced roughness values when compared to control groups. This new denture acrylic resin provides the benefit of enhancing C. albicans biofilm elimination through dual mechanisms of action, which could potentially reduce the prevalence of denture stomatitis.
Highlights
Microbiota of different microorganisms habitate in the oral cavity to protect the human body against infectious diseases [1], certain circumstances can favor the development of oral infections; these include immunodeficiency, malnutrition, poor oral hygiene and use of an ill-fitting removable dental prosthesis [2].Denture stomatitis (DS) is a chronic oral fungal infection characterized by erythema of the mucosa underlying the removable denture surface; usually the palatal mucosa of complete denture wearers [3]
The addition of 3% dimethylaminohexadecyl methacrylate (DMAHDM) alone or in combination with methacryloyloxyethyl phosphorylcholine (MPC) significantly reduced the flexural strength of the material when compared to groups without DMAHDM (p < 0.05)
Denture stomatitis is one of the most commonly encountered oral infections among denture wearers [4]. It is characterized by erythematous lesions on the oral mucosa, especially the palatal denture-bearing mucosa, due to their intimate contact with the removable denture [21]
Summary
Denture stomatitis (DS) is a chronic oral fungal infection (candidiasis) characterized by erythema of the mucosa underlying the removable denture surface; usually the palatal mucosa of complete denture wearers [3]. A removable acrylic resin denture should exhibit adequate physical, mechanical, and esthetic properties; the resinous nature of these materials renders them susceptible to microbial adhesion and growth, leading to denture stomatitis [5]. Local factors such as an ill-fitting dentures, rough or cracked denture surfaces, allergic reaction, poor salivary flow and the presence of candida in the mucosa facilitate the adherence and proliferation of Candida species on the surface of the denture base [6]
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