Abstract
Cognitive dysfunction in schizophrenia is associated with altered GABA signaling markers in the prefrontal cortex (PFC). For example, levels of somatostatin (SST) mRNA, expressed in a subset of GABA neurons, are markedly lower in PFC gray matter in schizophrenia. The density of SST mRNA+ neurons is also lower in schizophrenia. However, whether schizophrenia is associated with fewer SST neurons or a failure of certain SST neurons to express detectable levels of SST mRNA remains unknown.
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