Year-end Sale % OFF 
Abstract
Dengue viruses circulate in both human and sylvatic cycles. Although dengue viruses (DENV) infecting humans can cause major epidemics and severe disease, relatively little is known about the epidemiology and etiology of sylvatic dengue viruses. A 20-year-old male developed dengue hemorrhagic fever (DHF) with thrombocytopenia (12,000/ul) and a raised hematocrit (29.5% above baseline) in January 2008 in Malaysia. Dengue virus serotype 2 was isolated from his blood on day 4 of fever. A phylogenetic analysis of the complete genome sequence revealed that this virus was a member of a sylvatic lineage of DENV-2 and most closely related to a virus isolated from a sentinel monkey in Malaysia in 1970. This is the first identification of a sylvatic DENV circulating in Asia since 1975.
Highlights
Dengue viruses cause dengue fever (DF) and dengue hemorrhagic fever (DHF) in the tropics from Southeast and Southern Asia, the Caribbean, and many countries in South and Central America, and outbreaks are reported with increasing frequency globally
We report a case of dengue hemorrhagic fever from whom we isolated a dengue viruses (DENV)-2 which was determined by phylogenetic analysis to be a sylvatic strain most closely related to a virus isolated by Rudnick from a sentinel monkey in peninsular Malaysia in 1970 [5]
Through a fever surveillance programme, we identified a patient with DHF grade II who had been infected with a sylvatic strain of DENV-2
Summary
Dengue viruses cause dengue fever (DF) and dengue hemorrhagic fever (DHF) in the tropics from Southeast and Southern Asia, the Caribbean, and many countries in South and Central America, and outbreaks are reported with increasing frequency globally. The four distinct dengue virus serotypes (DENV-1 to DENV-4) belong to the family Flaviviridae and are among the most important vector-borne pathogens of humans, causing up to 100 million cases annually. Dengue viruses are mosquito-transmitted and circulate in both a sylvatic (enzootic) cycle involving non-human primates and various species of Aedes mosquito (such as Ae. furcifer, Ae. luteocephalus and Ae. taylori), and in a human (endemic) cycle principally vectored by Aedes aegypti [1,2,3]. Phylogenetic data suggests that sylvatic DENV are the ancestors of those viruses that circulate endemically in human populations [2]. We report a case of dengue hemorrhagic fever from whom we isolated a DENV-2 which was determined by phylogenetic analysis to be a sylvatic strain most closely related to a virus isolated by Rudnick from a sentinel monkey in peninsular Malaysia in 1970 [5]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
