Deneysel siklofosfamid toksikasyonunda sodyum selenit’in karaciğer ve böbrekte metallotiyonin ekspresyonu üzerine etkisinin araştırılması

Abstract

In this study, the effect of sodium selenite (SS) on metallothionine expression in liver and kidney tissues of rats administered cyclophosphamide (CP) at high dose intraperitoneally (i.p.) was investigated. In the study, a total of 24 Wistar Albino female rats with a weight of 200±10 g were used in 4 groups. Grouping in the study: Group I (Control group; daily 1 mL serum physiologique given as ip), Group II (CP group; 200 mg/kg/day CP administered as ip for 1 day), Group III (SS Group; 1 day ip 1 mg/kg/day SS was given as a treatment), Group IV (CP Group + SS Group; 200 mg/kg/day CP and 1 mg/kg/day SS was given as ip for 1 day) by forming 4 different groups. The effect of histopathological findings was found to be significantly lower in the group in which CP was given at high doses and SS was applied at the same time, compared to the group in which only CP was applied. When immunohistochemical findings related to MTs of liver and kidney tissues in this group were compared with histopathological findings, similar results were observed in terms of evaluation results. The study was concluded to be important in terms of animal and human health because SS is well tolerated in the organism and has no side effects at the appropriate dose.