Abstract
The intestinal mucosa is a preferential portal of entry for HIV-1 during mother-to-child transmission. Oral infection is also a well documented route for transmission of HIV-1 in neonates. Neonates can acquire the disease by breast-feeding, moreover presence of blood in gastric aspirates of neonates born to HIV-1 infected mothers has also been incriminated as a risk factor in the transmission of HIV-1. Multiple mechanisms for mucosal HIV-1 transmission have been proposed, however the exact role played by dendritic cells in facilitating viral passage across intestinal epithelium have not been fully defined. We had hypothesized that sub-mucosal dendritic cells (DCs) can mediate mucosal transmission of HIV-1 through a process similar to bacterial sampling through gastrointestinal epithelium (Rescigno M., Nat.Immun.2001).
Highlights
Fifth Dominique Dormont International Conference
The intestinal mucosa is a preferential portal of entry for HIV-1 during mother-to-child transmission
Multiple mechanisms for mucosal HIV-1 transmission have been proposed, the exact role played by dendritic cells in facilitating viral passage across intestinal epithelium have not been fully defined
Summary
Fifth Dominique Dormont International Conference. Host-Pathogen Interactions in Chronic Infections Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/pdf/1742-4690-6-S1-info.pdf . Dendritic cells sample HIV-1 through an intestinal epithelial cell monolayer Mariangela Cavarelli*1, Chiara Foglieni1, Maria Rescigno2 and Address: 1San Raffaele Scientific Institute, Milan, Italy and 2European Institute of Oncology, Milan, Italy * Corresponding author from Fifth Dominique Dormont International Conference. Mother-to-child transmitted viral diseases: from transmission to children care Paris, France.
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