Dendritic Cells Revisited.

Mar Cabeza-Cabrerizo,Carlos M Minutti,Mariana Pereira Da Costa,Caetano Reis E Sousa,Ana Cardoso

doi:10.1146/annurev-immunol-061020-053707

Mar Cabeza-Cabrerizo, Carlos M Minutti + Show 3 more

Open Access

https://doi.org/10.1146/annurev-immunol-061020-053707

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Journal: Annual Review of Immunology	Publication Date: Jan 22, 2021
Citations: 374	License type: CC BY 4.0

Affiliation: The Francis Crick Institute

Abstract

Dendritic cells (DCs) possess the ability to integrate information about their environment and communicate it to other leukocytes, shaping adaptive and innate immunity. Over the years, a variety of cell types have been called DCs on the basis of phenotypic and functional attributes. Here, we refocus attention on conventional DCs (cDCs), a discrete cell lineage by ontogenetic and gene expression criteria that best corresponds to the cells originally described in the 1970s. We summarize current knowledge of mouse and human cDC subsets and describe their hematopoietic development and their phenotypic and functional attributes. We hope that our effort to review the basic features of cDC biology and distinguish cDCs from related cell types brings to the fore the remarkable properties of this cell type while shedding some light on the seemingly inordinate complexity of the DC field.

Highlights

Found in all mammalian tissues, dendritic cells (DCs) are sentinel leukocytes that play a key role in the initiation and regulation of adaptive immune responses, as well as in innate immunity
We focus our discussion on the unique cell lineage that is nowadays called conventional or classical DCs
DC3 refers to a subpopulation of inflammatory cDC type 2 (cDC2)-resembling myeloid cells marked by low expression of IRF8 [132, 133], whereas DC4s, which lack expression of CD141 and CD1c and are identified by the surface marker CD16 [27], are possibly a subset of monocytes based on expression of CD16, CD14, and SLAN [126, 134]

Summary

Introduction

Found in all mammalian tissues, dendritic cells (DCs) are sentinel leukocytes that play a key role in the initiation and regulation of adaptive immune responses, as well as in innate immunity. Similar to many tissue macrophages, LCs maintain themselves by local proliferation in response to macrophage growth factors M-CSF (macrophage colonystimulating factor) and IL-34 [30] and do not depend on the cDC growth factor Flt3L [31] (see section titled Defining Conventional Dendritic Cells in the Mouse).

Results

Conclusion