Abstract
SummaryDendritic cells are mainly recognized for their potential to induce primary immune responses to foreign antigens. In allergic asthma, airway dendritic cells are at the very heart of the sensitization process, leading to stable Th2 immunity to commonly inhaled aeroallergens. Recently however, a role for dendritic cells beyond sensitization has been suggested. These studies show that airway DCs control the secondary immune response typical of late asthmatic reactions by recruiting and activating primed Th2 cells locally in the airways.
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