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Abstract
Dendritic cells (DC) are thought to play important roles as antigen presenting cells in the autoimmune insulitis preceding insulin dependent diabetes mellitus (IDDM). Not only are DC the first cells appearing in the pancreatic inflammatory process in animal models of diabetes (NOD mouse1.2 and BB rat3.4), DC are also abundantly present in progressed human insulitis5. Although insulitis in the NOD mouse starts around 3 weeks, overt diabetes will not develop until an age of 20 weeks. The lag between occult insulitis and diabetes, which can also be observed in human IDDM, was always considered to reflect the time needed for accumulation of a sufficient number of destructive T cells in the islets.
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