Abstract
<h3>Background</h3> Dendritic cell neurofibroma with pseudorosettes, first reported in 2001, is a benign peripheral nerve sheath tumor found in cutaneous tissues with a distinct histopathologic and immunohistochemical profile. Five cases have been reported in the oral cavity. <h3>Objective</h3> The sixth case of dendritic cell neurofibroma with pseudorosettes in the oral cavity with clinical and histopathologic findings and literature review is discussed. <h3>Findings</h3> A 72-year-old male patient presented with a 6-mm sessile soft tissue mass in the left soft palate. The clinical impression was fibroma, and an excisional biopsy was performed. Histopathology demonstrated an unencapsulated, well-circumscribed neural tumor composed of 2 cell populations arranged around acellular areas focally forming pseudorosettes. One cell population stained strongly positive for S100 and contained nuclei ranging in appearance from curvilinear to round; some of these cells resembled lymphocytes. The other cell population stained strongly positive for S100 and CD57 and contained vesicular nuclei and pseudoinclusions. A final diagnosis of dendritic cell neurofibroma with pseudorosettes was rendered on the basis of histologic examination with immunohistochemical analysis. <h3>Conclusions</h3> The sixth case of dendritic cell neurofibroma with pseudorosettes in the oral cavity was identified on the basis of the histopathologic and immunohistochemical profile. Five previous cases occurred in the dorsal tongue and buccal mucosa, whereas our patient's case occurred in the soft palate. Demographics of age and sex were similar for all 6 cases. This rare entity can mimic other soft tissue lesions clinically, including other benign peripheral nerve sheath tumors. Accurate diagnosis can render proper treatment for the patient.
Published Version
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