Abstract
Dendrimers are nanosized, symmetrical molecules in which a small atom or group of atoms is surrounded by the symmetric branches known as dendrons. The structure of dendrimers possesses the greatest impact on their physical and chemical properties. They grow outwards from the core-shell which further reacts with monomers having one reactive or two dormant molecules. Dendrimers' unique characteristics such as hyperbranching, well-defined spherical structure, and high compatibility with the biological systems are responsible for their wide range of applications including medical and biomedical areas. Particularly, the dendrimers' three-dimensional structure can incorporate a wide variety of drugs to form biologically active drug conjugates. In this review, we focus on the synthesis, mechanism of drug encapsulations in dendrimers, and their wide applications in drug delivery.
Highlights
Drug delivery is the utmost part of any dosage unit
PAMAM dendrimers make complexes with the nonsteroidal anti-inflammatory drugs and lead to enhanced permeation through the skin and act as permeation enhancers, for example, indomethacin [11]. All these resulting benefits lead to an exponential increase in the rapid and efficient synthesis of dendrimers along with their numerous applications in various areas such as catalysis, electronics, sensing, nanoengineering, diagnostics, and drug and gene delivery
Amine-terminated PAMAM dendrimers can solubilize different hydrophobic groups belonging to different families because the cationic charge present on the surface of the molecules disturbs the functionality of the cell membrane [16]
Summary
Drug delivery is the utmost part of any dosage unit. In order to ensure the targeted and effective drug delivery on an appropriate site without any configuration changes, preventing degradation, therapeutic activity, and stability, various polypeptide molecules are used. PAMAM dendrimers make complexes with the nonsteroidal anti-inflammatory drugs and lead to enhanced permeation through the skin and act as permeation enhancers, for example, indomethacin [11] All these resulting benefits lead to an exponential increase in the rapid and efficient synthesis of dendrimers along with their numerous applications in various areas such as catalysis, electronics, sensing, nanoengineering, diagnostics, and drug and gene delivery. Amine-terminated PAMAM dendrimers can solubilize different hydrophobic groups belonging to different families because the cationic charge present on the surface of the molecules disturbs the functionality of the cell membrane [16] These modification changes lead to changes such as becoming more sensitive, effective increase of transdermal permeation, and specific drug targeting.
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