Abstract
During the stage of viremia, viral antigen was demonstrable by means of immunofluorescence in the leucocytes of peripheral blood of experimental animals infected with vaccinia, lymphocytic choriomeningitis and rabies viruses. Specificity of the fluorescence observed was confirmed in each case by re-isolation of the virus from washed leucocytes by animal or tissue culture inoculation and the identity of re-isolated virus was established by neutralization or immunofluorescence techniques. Possibility of employing fluorescent antibody method for early diagnosis of viral infections is discussed.
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