Abstract
It is significant to develop an efficient early detection and prediction method for ovarian cancer via a facile and low-cost approach. To address such issues, herein, we develop a novel circulating tumor cell (CTC) detection method to sensitively detect ovarian cancer by using a flexible graphene-based biosensor on polyethylene terephthalate (PET) substrate. The results show that the graphene-based flexible biosensor demonstrates sensitive and rapid detection for ovarian cancer cells: it delivers obvious different responses for cell culture medium and cancer solution, different cancer cells and cancer cell solution with different concentrations; it demonstrates high sensitivity for detecting several tens of ovarian cancer cells per ml; moreover, the flexible graphene biosensor is very suitable for rapid and sensitive detection of ovarian cancer cells within 5 s. This work provides a low-cost and facile graphene biosensor fabrication strategy to sensitively and rapidly detect / identify CTC ovarian cancer cells.Graphical
Highlights
Ovarian cancer is the second most common gynecological cancer and has the highest mortality among the gynecological cancers [1, 2]
Imaging combined with carbohydrate antigen CA125 can be used in detection, diagnosing recurrences after surgery or chemotherapy
The cancer cell solution can be added into the cell pool, and the electrical signal of graphene biosensor can be obtained from two silver paste electrodes
Summary
Ovarian cancer is the second most common gynecological cancer and has the highest mortality among the gynecological cancers [1, 2]. The ovarian cancer patients are generally diagnosed very late due to the nonspecific symptoms of ovarian cancer and the lack of effective early screening methods. Imaging combined with carbohydrate antigen CA125 can be used in detection, diagnosing recurrences after surgery or chemotherapy. CA125 is not a single accurate marker for ovarian cancer because it is affected by numerous factors and has high false positive predictive value. The sensitivity of elevated CA125 (> 35 U/mL) which we used in the diagnosis of the recurrence of ovarian cancer is less than 70% [3]. Ultrasound examination and radiological examination have no adequate sensitivity nor specificity in early
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