Abstract
An androgen binding protein (called ABP) is present in 105,000 g av supernatants of rabbit testis and caput epididymidis but not in cauda. Testicular efferent duct fluid contains ABP in a concentration of 1.5 × 10 −7M, assuming one binding site per molecule of protein. Ligation of the efferent ducts causes ABP to increase in testis supernatant and disappear from supernatant of caput epididymidis. An androgen binding protein similar to ABP is present in rabbit serum; however, the concentrations of ABP per mg protein are much higher in efferent duct fluid and caput supernatant than in serum. These findings indicate that ABP is secreted in the testicular efferent duct fluid and may serve as a carrier of androgen from testis to epididymis.
Published Version
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