Abstract
Background: Corneal infections are the second most common cause of ocular blindness due to lack of diagnostic facilities and initiation of appropriate antimicrobial therapy. Suppurative Kerititis is defined as loss of corneal epithelium with underlying stromal infiltration and suppuration associated with signs of inflammation with or without hypopyon. The epidemiological pattern and causative agents for suppurative corneal ulcer varies. It is important to determine the aetiology for comprehensive strategy for the diagnosis and treatment of corneal ulcer. Materials and Methods: This is a prospective study conducted on 819 consecutive patients with clinical diagnosis of suppurative keratitis. Results: 819 cases with clinical diagnosis of suppurative keratitis were enrolled in this study. A history of previous corneal injury was present in 512 patients (62.5%). Central corneal ulcers were found in 680(83%) patients. Superficial corneal ulcers found in 699(85.3%) patients. Cornea cultures were positive in 730 patients (89%). Of those individuals with positive cultures 498 (60.8%) had pure bacterial infections, 232 (28.3%) had pure fungal infection.In this study of 498 bacterial isolates Staphylococcus.epidermidis 62.2%, Staph.aureus 32.12 % and Pseudomonas aeroginosa 4%. Conclusion: Trauma with stick and stone particles was an important cause. Staphylococcus.epidermidis and Staph.aureus were common bacteriological agents. . corneal ulceration is a common problem in India and most often occurs after a superficial corneal injury with organic material. Bacterial infections with Staph.epidermidis accounting for the majority of bacterial ulcers. These findings have important public health implications for the treatment and prevention of corneal ulcer.
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