Abstract
Specific binding sites for [125I][beta ]-endorphin and the [part ]1-opioid [3H][D-pen2, D-pen5]enkephalin (DPDPE) were quantified using autoradiography in soleus and extensor digitorum longus (EDL) muscles of lean and obese-diabetic (ob/ob) mice. The density of binding was significantly higher in obese-diabetic than lean mice. The uptake of 2-deoxy-D-[1-3H]deoxyglucose, a nonmetabolized glucose analogue, into isolated soleus and EDL muscles was stimulated by [beta ]-endorphin, [beta ]-endorphin 1-27, and DPDPE, but not by the [part ]2-opioid deltorphin II. Both [beta ]-endorphin and DPDPE stimulated deoxyglucose uptake in obese-diabetic mice. Thus, glucose transport in skeletal muscle may be partly mediated via [part ]1-opioid receptors. The increased receptor density in obese-diabetic mice may be an adaptive response.
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