Deletion of endothelial SIRT3 enhances endothelial dysfunction, vascular inflammation, and atherosclerosis

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Background and Aims: Atherosclerosis is the inflammation of vascular wall triggered by initial dysfunction of the luminal endothelial cells potentiated by dyslipidemia. Sirtuin 3 (SIRT3) is a nicotinamide adenine dinucleotide (NAD+) -dependent mitochondrial deacetylase. The present study tested whether endothelial-selective Sirt3 deletion accelerates vascular inflammation and atherosclerosis and the potential effect of L-arginine to alleviate vascular inflammation associated with SIRT3 deletion.