Abstract
Background and Aim:Cogon grass (Imperata cylindrica L.) (CGG) is a herbal medicine that could be developed into a male antifertility agent. The present study aims to determine the effect of an ethanol extract of CGG roots on mice testicular activity, reproductive hormone levels, and epididymal sperm quality.Materials and Methods:This study was designed as completely randomized with three different doses, such as an ethanol extract of CGG roots at 0 (control), 90, and 115 mg/kg body weight. In total, 21 male DDY mice strain were treated with the CGG extract (by gavage) for 14 days, followed by an evaluation of reproductive organs, epididymal sperm quality, testis histology, histomorphometry, and reproductive hormone assays. All quantitative data were analyzed by analysis of variance, followed by Tukey’s post hoc test at α=0.05.Results:The results showed that the administration of the CGG root ethanol extract disrupted the testis interstitial area and seminiferous tubules, resulting in decreased epididymal sperm quality as well as serum testosterone levels in a dose-dependent pattern.Conclusion:Oral administration of a CGG root ethanol extract induced testicular damage, decreased epididymal sperm quality, and impaired testosterone secretion.
Highlights
Fertility control is an exciting public health issue concerned with controlling overpopulation
The results showed that the administration of the CGG root ethanol extract disrupted the testis interstitial area and seminiferous tubules, resulting in decreased epididymal sperm quality as well as serum testosterone levels in a dosedependent pattern
To eliminate the effect of the CGG root ethanol extract on growth during the experiment, we evaluated the body weight (BW) and reproductive organ weight of the mice in the three groups
Summary
Fertility control is an exciting public health issue concerned with controlling overpopulation. Several contraceptive methods have been adopted for fertility control, but most are synthetic or costly and have many side effects. The most widely developed contraceptive methods have been for women, but side effects cannot be avoided. Male contraception acts by blocking sperm from fertilizing the egg either by physical barriers or Copyright: Widyastuti, et al Open Access. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/ publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. Cogon grass (Imperata cylindrica L.) (CGG) is a herbal medicine that could be developed into a male antifertility agent. The present study aims to determine the effect of an ethanol extract of CGG roots on mice testicular activity, reproductive hormone levels, and epididymal sperm quality
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