Abstract
Patients and methods: From November 2014 to March 2015, 158 childrenHBVvaccinatedwere recruited formeasuring antiHBV antibodies (antiHBs): 25 (15.8%) with CD, 63 (39.9%) with obesity, 42 (26.6%) with poor growth and 28 (17.7%) with abdominal pain. Weconsidered responsiveantiHBs levels >25 IU/ml. Toestimate the role ofHLA type inHBVv failure, in the subgroupwith antiHBs levels <25 IU/ml, HLA typing for CDwas evaluated; in these patients antibodies against transglutaminase (tTGA) and endomysium (EMA) were evaluated as well. Differences in frequencies between the groups were calculated by 2 test, considering significative values of p<0.05 (STATA MP12.1 Software). Results: A total of 69 (43.7%) children were seronegative for antiHBs; a significantly high proportion of subjects in the celiac group (18/25 – 72%) failed to respond to HBVv (p=0.0019). There was not a statistically significant association between obesity and HBVv response (29/63 – 46%; p=0.6261). Among nonresponders, 40/69 subjects (44.4%) had celiac-genotypes,without anypositivity for tTGA/EMA. Conclusions: We suggest to investigate children for HBV immune status; nonresponders should be revaccinated to achieve the goal of universal protection. No clear association was observed between celiac-genotypes and HBVv responsiveness.
Published Version
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