Abstract
Persistent behavioral and postural changes were detected in rats 4–5 days after rhythmic electrical stimulation of the right sensorimotor cortex, which evoked anxiety, aggressive behavior, and fear. Characteristic motor disorders were the manege moving, whose direction correlated with the turn of the head, retropulsions, rhythmic upward jerks of the head (tics), and orofacial dyskinesia (sniffing, mastication, and gnawing). These symptoms rose during 2–3 weeks and then attenuated albiet being retained in a weakened from throughout the entire (up to one year) observation period. The possible mechanisms of genesis of the delayed behavioral disorders and other neuropathophysiological syndromes evoked by rhythmic electrical stimulation of the sensorimotor cortex are discussed.
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