Abstract
In Reply.— Dr Mark referred to the association of epilepsy and abnormal behavior documented by references supporting this clinical finding. We also knew that this phenomenon existed but had the complicated clinical problem of finding which factors influenced our patient's condition and what treatment would be best for her. The most significant clinical change resulted after discontinuing the use of phenytoin, even though the phenytoin blood levels were much below toxic range and the patient had no other signs of phenytoin toxicity. We were not certain as to the cause of this abnormal behavior and psychosis, but the phenytoin clearly had an influence. Since we have reported this isolated occurrence, perhaps other physicians will find patients with a similar response to phenytoin or other anticonvulsants.
Published Version
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