Abstract
Cellular immunity has been studied in mice at various times during the induction of amyloidosis following multiple injections of casein. The assay system used was one which measured delayed hypersensitivity (DH) in vivo, by injecting antigen into the left ear lobe of sensitized mice, followed by the intravenous administration of 125I-deoxyuridine ( 125I-UdR). The ears were then cut off and the L R 125I-UdR ratio provided a measure of DH. It was found that DH to casein appeared in pre-amyloidotic mice, remained through the stages of mild and moderate amyloidosis and disappeared in severely amyloidotic mice. DH to fowl IgG disappeared after three injections of casein and remained absent at all times thereafter, likely due to antigenic competition. In contrast, DH to DNFB persisted at all times, even in the face of severe amyloidosis. These results have been interpreted to indicate that, using this assay, DH is normal during casein-induced murine amyloidosis.
Published Version
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