Abstract
Guinea pig delayed hypersensitivity (DH) to tissue spherules of Coccidioides immitis was adoptively (passively) transferred to mice with dialyzable transfer factor (TF), and assayed by a footpad swelling (FPS) method. FPS was measured by the weight-difference between the test foot and the contralateral one. The intensity of FPS reaction correlated directly with the macrophage migration inhibition test response of guina pig peritoneal cells. The local transfer of DH to C. immitis may serve as a simple animal model for assay of guinea pig TF released in vitro from lysed peritoneal cells, or in vivo with plasma from guinea pigs sensitized to C. immitis after induction of anergy to C. immitis (specific lysis of immune lymphocytes in vivo with excess of coccidioidal antigen given intracutaneously into 8 sites on the back of the guinea pig).
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