Abstract
Dialysable Transfer Factor was prepared from a large pool of normal adult donor leukocytes following Lawrence’s technique. This homogeneous preparation was injected into 3 normal recipients and 14 patients with immunodeficiencies: 5 ataxia telangiectasia, 4 Wiskott-Aldrich syndrome, 2 variable hypogammaglobulinemia, 2 combined immunodeficiencies and one chronic mucocutaneous candidiasis. Transfer of delayed hypersensitivity of several antigenic markers was achieved in 13 cases. Streptokinase — streptodornase and Candida albicans gave the highest incidence of positive tests among adult donors and recipients. 5 recipients developed a positive reaction to DNCB, a chemical to which none of the donors was sensitized.
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