Abstract
Abstract Thermal injury was induced in the cremaster muscle of rats by application of a heated (54°C) copper disc to the scrotal skin for 40 seconds. Carbon was injected intravenously at various intervals after injury and the cremaster was examined with the light and electron microscope. By light microscopy, carbon deposition was localized in medium-sized venules in the immediate phase of vascular leakage. During the delayed phase, 2–4 hours after injury, most of the blackened vessels were small venules and capillaries. By electron microscopy, leakage of carbon occurred through discrete gaps in the endothelium in the majority of leaking vessels at all intervals after injury. In addition, signs of endothelial damage and occasional necrosis were present in the delayed phase, especially in the smaller vessels. The significance of these findings was discussed in relation to the mechanisms involved in the immediate and delayed phases of increased vascular permeability.
Published Version
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