Delay first active-phase meal, breakfast-skipping model, increases the risk of metabolic disorders in females rats

Abstract

ABSTRACT The absence or delay of 4h of food supply in the beginning of the dark phase of the cycle in rats is related to the increase in visceral fat pads, and biochemical changes. Four groups (n = 34, Wistar rats) were formed from the diet and food restriction protocol: Control (C), Restricted Control (RC), Westernized Diet (W) and Restricted Westernized Diet (RW). Body weight, glucose and serum lipids, oral glucose tolerance test, visceral and liver fat were analyzed. It considered a significance level of 5%. Delaying the meal at the beginning of the active phase of the cycle did not change body weight, but increased visceral fat by 85%, 36% and 67% in RC, W and RW, respectively, compared to C. the groups that increased deposits of visceral fat had a concomitant reduction in food intake, with the exception of CR. The use of a Westernized diet did not change the glycemic curve, but it showed resistance to a fall in glucose to baseline levels, a reduction in HDLc and fasting hyperglycemia. The Westernized diet and delayed first meal in females caused hyperglycemia, increased visceral fat, and greater infiltration of liver fat as a result of the diet.