Abstract
The process of degranulation and regranulation of pancreatic islet cells was followed in the male rats given one intramuscular or intraperitoneal injection of alloxan (200 mg/Kg). The serum glucose showed a typical triphasic curve, reaching permanent hyperglycemia 24 hours after injection. The insulin levels of both serum and pancreas have been subnormal for the first 24 hours and then marked decrease of insulin levels was observed on the third day thereafter. In accord with subnormal pancreatic insulin levels, B granules have been present in the necrotic cells up to the first 24 hours, then complete disappearance was observed on the third day. Histochemistry of zinc was parallel to the preservation of B cells. Reactive zinc decreased from the center of the islets In 2–4 hours after alloxan, and after 24 hours zinc reaction was positive only around the periphery of the islets. Regranulated islet cells were observed from 7 days through 28 days in the presence of permanent diabetes with decreased population of B cells.
Published Version
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