Abstract
Degradation represents a strategy to improve the biopharmaceutical properties of native algae sulfated polysaccharides (SP) with high Mw. The aim of this study was to compare the degradability of four sulfated xylogalactans (SXG) and four fucose-rich sulfated polysaccharides (FRSP) extracted from red and brown algae, respectively, using three simple methods causing no desulfation as well as to examine the chemical and pharmacological changes of the resulting fractions. The achieved degradation proved to be dependent on the basic glycan structure of the SP. Treatment with hydrogen peroxide (3%, 4 h, 50 °C) led to the most efficient degradation of both FRSP and SXG. The Mw decrease was associated with distinct reduction of the activities (complement inhibition (>) elastase inhibition > C1-INH potentiation) and resulted in a modified pharmacological profile. Despite their much lower degree of sulfation, some of the fractions with Mw < 15 kDa exhibited similar or even stronger activities than heparins, whereas they had only weak anticoagulant effects.
Published Version
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