Abstract
The in vitro degradation of polylactic acid of different weight average molecular weight ( M w) in microspheres containing variable amounts of methadone base (between 17 and 47%) was studied using the degradation index (DI), polidispersivity (pd) and molecular weights distribution. Both pd and DI are independent of initial methadone content and increase with M w polymer, showing values of DI around 6.6 for the high M w and 2.9 for the lower M w. The distribution functions in the number of the molecular weights during the degradation assays indicate the presence of different break mechanisms for high and low molecular weight chains. A semiempiric model is proposed to explain the evolution of M n during degradation in function of the number of bonds available for their breaking and hydrolysis rate constant. The first parameter ranges between 2.35 and 6.65 in function of M w; the hydrolysis rate constant is independent of M w and equal to 0.020 h −1 (SD = 0.011 h −1).
Published Version
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