Abstract
Polylactic acid (PLA) is one of the most promising candidates to solve the present environmental and energy problems. The programmable three-dimensional (3D) fabrication technique also provides a convenient and green platform for PLA applications in bone tissue engineering. An innovative PLA scaffold that combined multiple functions including highly interconnected porosity, sufficient nutrient supply, and antibacterial activity was prepared through 3D printing. Porosity of the scaffold was 67%, which was quite desirable for cell adherence and immigration. Followed by dopamine polymerization on the surface of the substrate, grafting with gelatin/nanohydroxyapatite (nHA) and ponericin G1 was further conducted. Scanning electron microscopy (SEM) and X-ray photoelectron spectroscopy (XPS) confirmed the successful modification. MC3T3-E1 cell culture showed a uniform distribution all through the scaffold with high survival rate, which was also confirmed by live/dead staining. Polydopamine modification made the ...
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