Abstract
The paper deals with investigation of deformation behaviour of gellan gum (GG) based structures prepared for regenerative medicine purposes. Investigated material was synthesized as porous spongy-like scaffold reinforced by bioactive glass (BAG) nano-particles in different concentrations. Deformation behavior was obtained employing custom designed experimental setup. This device equipped with bioreactor chamber allows to test the delivered samples under simulated physiological conditions with controlled flow and temperature. Cylindrical samples were subjected to uniaxial quasistatic loading in tension and compression. Material properties of plain GG scaffold and reinforced scaffold buffered by 50wt% and 70wt% BAG were derived from a set of tensile and compression tests. The results are represented in form of stress-strain curves calculated from the acquired force and displacement data.
Highlights
The worldwide incidence of bone disorders and conditions have trended steeply upward
More than 40 % of women and 30 % of men are at increased risk of emergence of bone disorders [2]
Material properties and deformation behaviour of plain gellan gum (GG) scaffold and GG-bioactive glass (BAG) reinforced scaffold with 50 wt% and 70 wt% BAG content were studied in tensile and compression tests under dry and wet conditions
Summary
The worldwide incidence of bone disorders and conditions have trended steeply upward. High income regions are expected twofold increase between 2010 and 2020 [1]. This is the tribute for populations aging coupled with improper nutrient consumption and poor physical activity. More than 40 % of women and 30 % of men are at increased risk of emergence of bone disorders [2]. In the USA only, more than half a million bone defects are reported. Worldwide the treatment cost reaches more than $2.5 billion
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