Abstract
This study is focuses on an investigation of the reinforcement effect of the bioactive glass nano-particles in the gellan gum (GG) scaffolds used in bone tissue engineering. The investigated material was synthesized as the porous spongy-like structure improved by the bioactive glass (BAG) nano-particles. Cylindrical samples were subjected to a uniaxial quasi-static loading in tension and compression. Very soft nature of the material, which makes the sample susceptible to damage, required employment of a custom designed experimental device for the mechanical testing. Moreover, as the mechanical properties are significantly influenced by testing conditions the experiment was performed using dry samples and also using samples immersed in the simulated body fluid. Material properties of the pure GG scaffold and the GG-BAG reinforced scaffold were derived from a set of tensile and compression tests under dry and simulated physiological conditions. The results are represented in the form of stress-strain curves calculated from the acquired force and displacement data.
Highlights
The worldwide incidence of bone disorders and conditions is growing by steeply increasing trend
This study is focused on an investigation of the reinforcement effect of the bioactive glass nano-particles in the gellan gum (GG) scaffolds used in bone tissue engineering
The GG-bioactive glass (BAG) samples with different fraction of the reinforcing BAG particles were subjected to optically evaluated uni-axial measurements under both dry and wet conditions
Summary
The worldwide incidence of bone disorders and conditions is growing by steeply increasing trend. In the high income regions, a twofold increase between 2010 and 2020 is expected [1]. This is the tribute for populations aging coupled with improper nutrient consumption and poor physical activity. More than 40 % of women and 30 % of men are under increased risk of occurence of bone disorders [2]. Only in the USA more than half a million bone defects are reported. The treatment expenditures reach more than $2.5 billion per year
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