Abstract
Deep-Fried Signaling: tempura Gets Notch Cooking
Highlights
As a multicellular animal’s tissues mature throughout embryogenesis, its cells must communicate with each another to determine their appropriate placement and physiological role. This communication takes place through longrange, secreted signals; in others, through direct cell-cell contact. One example of the latter case is a process called lateral inhibition, wherein a developing neuronal precursor cell presents a signal to neighboring cells that prevents them from adopting the neuroblast cell fate
In their paper published in this month’s PLoS Biology, Wu-Lin Charng, Hugo Bellen, and colleagues set out to look for new proteins that influence Notch signaling
If Notch signaling is blocked during fly development, it leads to a failure of lateral inhibition and cell fate specification during external sensory organ (ESO) development
Summary
As a multicellular animal’s tissues mature throughout embryogenesis, its cells must communicate with each another to determine their appropriate placement and physiological role. In their paper published in this month’s PLoS Biology, Wu-Lin Charng, Hugo Bellen, and colleagues set out to look for new proteins that influence Notch signaling. To identify proteins involved in the Notch pathway, Charng and colleagues took advantage of a highly visible change caused by loss of Notch activity.
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