Deep Phenotypic Cell Classification using Capsule Neural Network.

Abstract

Recent developments in ultra-high-throughput microscopy have created a new generation of cell classification methodologies focused solely on image-based cell phenotypes. These image-based analyses enable morphological profiling and screening of thousands or even millions of single cells at a fraction of the cost. They have been shown to demonstrate the statistical significance required for understanding the role of cell heterogeneity in diverse biologists. However, these single-cell analysis techniques are slow and require expensive genetic/epigenetic analysis. This treatise proposes an innovative DL system based on the newly created capsule networks (CapsNet) architecture. The proposed deep CapsNet model employs "Capsules" for high-level feature abstraction relevant to the cell category. Experiments demonstrate that our proposed system can accurately classify different types of cells based on phenotypic label-free bright-field images with over 98.06% accuracy and that deep CapsNet models outperform CNN models in the prior art.