Deep Open-Curve Snake for Discriminative 3D Neuron Tracking.

Abstract

Open-Curve Snake (OCS) has been successfully used in three-dimensional tracking of neurites. However, it is limited when dealing with noise-contaminated weak filament signals in real-world applications. In addition, its tracking results are highly sensitive to initial seeds and depend only on image gradient-derived forces. To address these issues and boost the canonical OCS tracker to a new level of learnable deep learning algorithms, we present Deep Open-Curve Snake (DOCS), a novel discriminative 3D neuron tracking framework that simultaneously learns a 3D distance-regression discriminator and a 3D deeply-learned tracker under the energy minimization, which can promote each other. In particular, the open curve tracking process in DOCS is formed as convolutional neural network prediction procedures of new deformation fields, stretching directions, and local radii and iteratively updated by minimizing a tractable energy function containing fitting forces and curve length. By sharing the same deep learning architectures in an end-to-end trainable framework, DOCS is able to fully grasp the information available in the volumetric neuronal data to address segmentation, tracing, and reconstruction of complete neuron structures in the wild. We demonstrated the superiority of DOCS by evaluating it on both the BigNeuron and Diadem datasets where consistently state-of-the-art performances were achieved for comparison against current neuron tracing and tracking approaches. Our method improves the average overlap score and distance score about 1.7% and 17% in the BigNeuron challenge data set, respectively, and the average overlap score about 4.1% in the Diadem dataset.