Abstract

Fundus image is an image that captures the back of the eye (retina), which plays an important role in the detection of a disease, including diabetic retinopathy (DR). It is the most common complication in diabetics that remains an important cause of visual impairment, especially in the young and economically active age group. In patients with DR, early diagnosis can effectively help prevent the risk of vision loss. DR screening was performed by an ophthalmologist by analysing the lesions on the fundus image. However, the increasing prevalence of DR is not proportional to the availability of ophthalmologists who can read fundus images. It can lead to delayed prevention and management of DR. Therefore, there is a need for an automated diagnostic system as it can help ophthalmologists increase the efficiency of the diagnostic process. This paper provides a deep learning approach with the concatenate model for fundus image classification with three classes: no DR, non-proliferative diabetic retinopathy (NPDR), and proliferative diabetic retinopathy (PDR). The model architecture used is DenseNet121 and Inception-ResNetV2. The feature extraction results from the two models are combined and classified using the multilayer perceptron (MLP) method. The method that we propose gives an improvement compared to a single model with the results of accuracy, and average precision and recall of 91% and 90% for the F1-score, respectively. This experiment demonstrates that our proposed deep-learning approach is effective for the automatic DR classification using fundus photo data.

Highlights

  • Introduction published maps and institutional affilDiabetes is characterised by hyperglycaemia and impaired carbohydrate, lipid, and protein metabolism related with absolute or relative insulin activity or secretion [1]

  • We applied fundus image pre-processing to the Dataset for Diabetic Retinopathy (DDR) dataset we had previously collected

  • We applied fundus image pre-processing to the DDR dataset we had previously ously ously collected

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Summary

Introduction

Diabetes is characterised by hyperglycaemia and impaired carbohydrate, lipid, and protein metabolism related with absolute or relative insulin activity or secretion [1]. The estimated worldwide prevalence of diabetes in 2019 was 9.3% (463 million people), and in 2045 is expected to continue to increase to 10.9% (700 million people) [2]. Hyperglycaemia that is not well controlled can lead to complications of diabetes, such as nephropathy, retinopathy, neuropathy, and cardiovascular disease [3]. The most common complication is diabetic retinopathy (DR), a significant cause of visual impairment, especially in the younger and economically active age group. More than 4 million people experience sight loss due to DR, of which 3.3 million have moderate-to-severe visual impairment and the rest are blind [4].

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