Abstract
The work outlined herein describes an evaluation of a green solvent working as a drug solubility and penetration enhancer made up of a deep eutectic system (DES) composed of menthol (MN) and capric acid (CA). Risperidone (RIS) was tested as a class II model drug. The system efficacy in enhancing drug solubility was carried out at five different CA: MN mass ratios (w/w) of 7:3, 6:4, 5:5, 4:6, and 3:7. The 7:3 CA:MN (w/w) mass showed the most remarkable solubility improvement of the drug of up to 73000-fold compared to water. The phase-forming mechanics involved in drug-related solubility were demonstrated in this work by studying the mixtures’ viscosity and contact angle at the same above-mentioned CA:MA ratios. Moreover, the interactions between the components that constitute the DES were studied using DSC and FTIR analysis. Results confirmed that H-bonds between MN and CA formed the DES. The permeability of the systems was established through diffusion studies carried out using Franz cell. Preparations comprising the drug in DES showed the absence of any acute skin irritation/erosion effect on Wistar rats.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
