Abstract
肌萎缩侧索硬化（ALS）是一种同时累及上、下运动神经元的神经系统变性病，发病机制尚不明确。从20世纪中期起，研究发现并证实对ALS患者进行重复神经电刺激（RNS）时可观测到低频递减反应，递减反应在上肢较下肢常见，肢体近端较远端更为明显。多数研究认为ALS出现递减反应和病程、疾病分期、临床进展无关。RNS低频递减反应可以辅助ALS进行诊断和鉴别诊断。本文对近几年ALS患者RNS研究中采用的方法，低频递减的临床特征、临床意义及理论支持进行综述，同时对RNS在ALS的诊治应用上进行展望。.
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