Decreasing prevalence and time trend of gastroschisis in 14 cities of Liaoning Province: 2006-2015.

Na Li,Cai-Xia Liu,Li-Li Li,Yan-Hong Huang,Chen Zhou,Jing Li,Cheng-Zhi Jiang,Ting-Ting Gong,Da Li,Yan-Ling Chen,Qi-Jun Wu

doi:10.1038/srep33333

Na Li, Cai-Xia Liu + Show 9 more

Open Access

https://doi.org/10.1038/srep33333

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Abstract

To identify trends in the prevalence of gastroschisis on the basis of a large population-based observation study with cases identified by the Liaoning Birth Defects Registry including 14 cities over the course of a 10-year period. Data were obtained from the aforementioned registry which was maintained by the Liaoning Women and Children’s Health Hospital, a comprehensive care institution as well as being responsible for the women’s and children’s health care guidance in this province. Gastroschisis prevalence, percent change, annual percent change (APC), and contribution rates of each city were calculated. We observed 747 cases of gastroschisis among 3,248,954 live births, for a prevalence of 2.30 per 10,000 births. The gastroschisis prevalence significantly decreased by 12.63% per year in Liaoning Province. Although the decreasing trends were observed in all these 14 cities, significant results were only observed in Shenyang (APC = −16.31%), Tieling (APC = −20.23%), and Chaoyang (APC = −13.50%). Notably, Tieling, Shenyang, and Yingkou were the three major cities which contributed almost 37.17% of the decreasing trend of gastroschisis in Liaoning Province. In conclusion, our findings demonstrate that the prevalence of gastroschisis has been decreasing during the recent decade among 14 cities in Liaoning Province.

Highlights

Gastroschisis is the evisceration of the fetal intestine through a defect in the paraumbilical anterior abdominal wall with herniation of gastrointestinal structures into the amniotic cavity[1]
During 2006–2015, 747 gastroschisis cases were detected among 3,248,954 live births
Our findings demonstrated prevalence of gastroschisis significantly decreased by 76.05% from 33.58 to 8.04 per 10,000 live births, or 12.63% per year for the 10-year period from 2006 through 2015 in Liaoning Province

Summary

Introduction

Gastroschisis is the evisceration of the fetal intestine through a defect in the paraumbilical anterior abdominal wall with herniation of gastrointestinal structures into the amniotic cavity[1] Babies born with this condition are more likely to be born prematurely and to have had poor fetal growth[1]. To the best of knowledge, no study has demonstrated the time trends and prevalence of gastroschisis in China by the data of the recent decade. Whether prevalence of this disease has continued to be constant has been still unknown. No formal assessment of this population had been made To address these aforementioned research questions, we examines gastroschisis prevalence among live birth infants in Liaoning Province for the 10-year period from 2006–2015

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Results

Conclusion