Abstract
Background: Radiotherapy has long been recognized as the mainstay for the treatment of nasopharyngeal carcinoma with or without chemotherapy. Chemoradiotherapy can induce a transformation of thyroid gland causing thyroid disorder. Objective: This study has evaluated a decrease in thyroid function in patients with nasopharyngeal carcinoma who received chemoradiotherapy. Methods: This is a pre-post study design. The subject includes patients with nasopharyngeal carcinoma that underwent chemoradiotherapy. Patient's thyroid functions were measured twice; before and 3 months after chemoradiotherapy. Results: We observed the result of 30 patients that underwent chemoradiotherapy. The results of pre and post treatment for FT3, FT4 and TSH show p-value of 0,001, 0,0043 and 0,015 respectively showing statistically significant difference between two measurement period. Conclusion: We found an alteration in thyroid function in patients with nasopharyngeal carcinoma who received chemoradiotherapy.
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