Abstract
BACKGROUND: Patients with atopic dermatitis (AD) are susceptible to cutaneous infection with Staphylococcus aureus or herpes simplex virus, which may be related to the reduced expression of antimicrobial peptides. Skin lesions with AD are associated with dysregulated expression of LL-37 and enhanced expression of IL-22, thymic stromal lymphopoietin (TSLP), IL-25, IL-31, and oncostatin M. Vitamin D3 enhances LL-37 production in keratinocytes. This study aimed to examine the serum levels of LL-37 and vitamin D3 and their regulation of cytokine production in patients with AD.
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