Abstract
Background and Objective:Parathormone (PTH) and serum Vitamin D3 (VD3) share a complex interplay where increased VD3 leads to a negative response on parathormone level. Our objective was to determine the correlation of parathormone (PTH) and Vitamin D3 (VD3) levels in nursing mothers and infants 1-6 months’ age from South Punjab, Pakistan.Methods:This study is a secondary data analysis of previously conducted cross sectional study which was conducted at the Department of Pediatric Medicine, Nishtar Medical University, Multan, during August 2010 to June 2011. Study included 67 infants 1-6 months of age and 60 nursing mothers. A venous blood sample was drawn for estimation of VD3, calcium, phosphate, alkaline phosphatase, parathormone and albumin. Spearman correlation coefficient was calculated to determine the inverse correlation between PTH and VD3 levels.Results:Mean age (in days) of the infants was 83±53.7 days whereas maternal mean age was 25.53 ± 4.12 years. Median VD3 level in infants was 20.90 ng/ml (IQR – 49.5). Median serum PTH levels were 20.90 pg/ml (IQR – 26.17). Median VD3 level in nursing mothers was 21.0 ng/ml (IQR 7.2– 43.8). Median maternal serum PTH levels were 20.89 pg/ml (IQR 2.9 – 232.4). Substantial negative relation between VD3 and parathormone in infants and mothers was not evident (r = - 0.027, p-value 0.83) and (r = 0.156, p-value 0.23) respectively. A significant positive association between infant and maternal VD3 was observed (rs –0.55, p-value < 0.001).Conclusion:Our study affirms that the customary negative correlation between VD3 and parathormone levels does not exist.
Highlights
The Parathormone (PTH) and serum Vitamin D3 (VD3) share a complex interplay where increased calcium and VD3 exert a negative feedback on PTH level that has been shown by multiple studies.[1]
This study is secondary data analysis of our previous studies that aimed to determine the VD3 status and determinants of low VD3 in nursing mothers and infants 1 – 6 months of age, which was conducted at Department of Pediatric Medicine and approved by ethical review committee of Nishtar Medical University (ERC#15864-77 dated July 14, 2016)
The eligibility criteria for Infants included 1-6 months of age who visited for routine immunization, those admitted with acute respiratory illness in the Pediatric Medicine Department and whose parents were willing to participate in the study
Summary
The Parathormone (PTH) and serum Vitamin D3 (VD3) share a complex interplay where increased calcium and VD3 exert a negative feedback on PTH level that has been shown by multiple studies.[1] Lower level of VD3 in the body decreases intestinal calcium and phosphorus absorption and triggers the parathormone secretion through calcium-sensing receptors. This increased concentration of PTH in serum leads to increased. Conclusion: Our study affirms that the customary negative correlation between VD3 and parathormone levels does not exist
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