Abstract
Decreased production of soluble interleukin 2 receptor by phytohaemagglutinin-stimulated peripheral blood mononuclear cells in patients with breast cancer after adjuvant therapy
Highlights
Group 2 contained 23 patients with distant metastases who were undergoing combined cytostatic chemotherapy including adriamycin or mitoxantrone
A horseradish peroxidase-conjugated anti-IL-2R monoclonal antibody directed against a second epitope on the soluble interleukin 2 receptor (sIL-2R) molecule binds to the sIL-2R captured by the first antibody
After a washing step to remove unbound enzyme-conjugated antisIL-2R antibody, a substrate solution was added to the wells, the reaction was stopped after 30min and the absorbence was determined at 490 nm
Summary
Group 2 contained 23 patients with distant metastases who were undergoing combined cytostatic chemotherapy including adriamycin or mitoxantrone. SIL-2R levels assessed in sera derived from patients with non-metastatic (319.7 ± 100.3 U ml-') or metastatic (440.9 ± 183.4 U ml- ') breast cancer or from healthy control individuals (404.2 ± 245 U ml-') did not differ significantly from each other
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