Abstract
Alzheimer’s disease is a neurodegenerative disorder characterized with progressive im-pairment of cognitive functions. Heme oxygenase is an enzyme that degrades the heme molecule resulting in equimolar amounts of the carbon monoxide, ferrous iron, and bili-verdin. Up to now, heme oxygenase activity and its metabolic effects in Alzheimer’s dis-ease have been investigated in so many studies; most of them were performed in post-mortem brain tissues of Alzheimer’s disease patients or in animal models. Therefore, we aimed to investigate heme oxygenase activity in leukocytes of Alzheimer’s disease pa-tients as a peripheral sample. Mean heme oxygenase activity was significantly lower in patients with Alzheimer’s disease (0.53 ± 0.32 nmol/h/mg protein) compared to control sucjects (1.19 ± 0.84 nmol/h/mg protein) (p= 0.001). We think that reduction in leukocyte heme oxygenase activity may limit disease progression through preserving peripheral mitochondrial function by reducing the formation of free iron and carbon monoxide.
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