Abstract
The thymus is a critical organ for the elimination of autoreactive T cells by apoptosis. We studied the expression of apoptosis-associated genes, bcl-xL, bad, caspase-3, and c- myc family genes in myasthenia gravis (MG) thymuses. We observed that the mRNA levels of myc family genes, c- myc and max, were markedly reduced in MG thymuses. These results indicate that c- myc-mediated signaling is abnormal in MG thymuses. The levels of molecules whose expressions are associated with myc, such as STAM, prothymosin-alpha, and NFkappaB, were also analyzed.
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