Abstract
The effect of dextran sulfate on aminoglycoside concentration in rat renal cortex was studied. Dextran sulfate has one class involving many binding sites for aminoglycosides. Gentamicin has a higher affinity for dextran sulfate than either amikacin or dibekacin. A complex of dextran sulfate and gentamicin had no influence on the elimination of gentamicin from the blood, but gentamicin concentration in the renal cortex showed a significant decrease. The binding of gentamicin to brush-border membrane vesicles was inhibited non-competitively by dextran sulfate. Substantial amounts of administered dextran sulfate were found in the urine, possibly indicating that dextran sulfate may inhibit the interaction between aminoglycoside and brush-border membranes at the lumen of the renal proximal tubule. There is thus the possibility that dextran sulfate may effectively inhibit the distribution of aminoglycosides on the reabsorption process and decrease the accumulation within the renal cortex.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
