Abstract
Prostaglandin E 1 (PGE 1) sensitive adenylate cyclase [EC.4.6.1.1 ATP-pyrophosphate lyase (cyclizing)] in human platelet lysates is inhibited by dextran sulfate. Inhibition is dose-dependent at the range of 1–10 μg/ml. Maximal inhibition obtained was 83% at 30 μg/ml. At a similar range of concentrations dextran sulfate was found to antagonize the anti-aggregating effect of PGE 1 on adenosine S' diphosphate (ADP) induced human platelet aggregation. Heparin, like dextran sulfate, effectively antagonizes the anti-aggregating effect of PGE 1 in human platelets. It is possible that the aggregating effects of both heparin and dextran sulfate on human platelets may be mediated via inhibition of platelet PGE 1-sensitive adenylate cyclase.
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