Abstract

ACTH administration to pregnant mice, at both 1- and 8-IU dosages, altered the subsequent aggressive behavior of the offspring. The proportion, intensity, and duration of fighting in males were decreased in comparison to those in controls. A second experiment found that the female offspring of ACTH-treated pregnant animals also were deficient in the aggressive behavior initiated by exposure to testosterone propionate in adulthood. The possible long-term effects of the ACTH treatment on androgen responsiveness and brain chemistry are discussed.

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