Abstract
Magnolia plants are used both as food supplements and as cosmetic and medicinal products. The objectives of this work consisted of preparing extracts from leaves and flowers of eight Magnolia plants, and of determining concentrations of magnolol (1 to 100 mg·g−1), honokiol (0.11 to 250 mg·g−1), and obovatol (0.09 to 650 mg·g−1), typical neolignans for the genus Magnolia, in extracts made by using a methanol/water (80/20) mixture. The tested Magnolia plants, over sixty years old, were obtained from Průhonický Park (Prague area, Czech Republic): M. tripetala MTR 1531, M. obovata MOB 1511, and six hybrid plants Magnolia × pruhoniciana, results of a crossbreeding of M. tripetala MTR 1531 with M. obovata MOB 1511. The identification of neolignans was performed by HRMS after a reversed-phase high-performance liquid chromatography (RP-HPLC) fractionation of an extract from M. tripetala MTR 1531. The highest concentrations of neolignans were found in the flowers, most often in their reproductive parts, and obovatol was the most abundant in every tested plant. The highest concentrations of neolignans were detected in parent plants, and lower concentrations in hybrid magnolias. Flower extracts from the parent plants M. tripetala MTR 1531 and M. obovata MOB 1511, flower extracts from the hybrid plants Magnolia × pruhoniciana MPR 0271, MPR 0151, and MPR 1531, and leaf extract from the hybrid plant Magnolia × pruhoniciana MPR 0271 inhibited growth of Staphylococcus aureus.
Highlights
Magnolia plants have been grown for decorative purposes in Europe and America, while in Asia these plants have been used in traditional medicine for centuries in order to treat gastrointestinal disorders, anxiety, cough, allergies, or asthma [1]
Antimicrobial, antioxidant, antitumor, and neuroprotective effects or cardiovascular protective effects have been demonstrated with many secondary metabolites of the genus Magnolia [5,6,7]
We studied the content of neolignans in leaves and flowers of Magnolia plants, and we found that the flowers of the tested Magnolia plants were richer in neolignans than the leaves
Summary
Magnolia plants have been grown for decorative purposes in Europe and America, while in Asia these plants (especially M. officinalis and M. obovata) have been used in traditional medicine for centuries in order to treat gastrointestinal disorders, anxiety, cough, allergies, or asthma [1]. The most commonly studied secondary metabolites of this genus include neolignans, namely magnolol, honokiol, and obovatol. For the above-mentioned reason, investigation has been focused on on analyzing quantities of secondary metabolites in parts of Magnolia plants other than its bark [6,7]. Magnolia plants, (b) analyzing the concentration of magnolol, honokiol, and obovatol, neolignans. Magnolia plants, (b) analyzing the concentration of magnolol, honokiol, and obovatol, neolignans typical for the genus Magnolia, obtained by extraction using a methanol/water (80/20, v/v) mixture typical for the genus Magnolia, obtained by extraction using a methanol/water (80/20, v/v) mixture and subsequent extraction of the organic layer by chloroform, and (c) determining the antimicrobial and subsequent extraction of the organic layer by chloroform, and (c) determining the antimicrobial effects of the extracts.
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